A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism.
Synthetic Lethality (SL) is currently defined as a type of genetic interaction in which the loss of function of either of two genes individually has Lacrosse - Protective - Shoulder Pads limited effect in cell viability but inactivation of both genes simultaneously leads to cell death.Given the profound genomic aberrations acquired by tumor cells,