A NETWORK-BASED APPROACH TO INTEGRATE NUTRIENT MICROENVIRONMENT IN THE PREDICTION OF SYNTHETIC LETHALITY IN CANCER METABOLISM.

A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism.

Synthetic Lethality (SL) is currently defined as a type of genetic interaction in which the loss of function of either of two genes individually has Lacrosse - Protective - Shoulder Pads limited effect in cell viability but inactivation of both genes simultaneously leads to cell death.Given the profound genomic aberrations acquired by tumor cells,

read more

Towards better correlation of the Central Paratethys regional time scale with the standard geological time scale of the Miocene Epoch

Depositional sequences originating in semi-enclosed basins with endemic biota, Lacrosse - Protective - Shoulder Pads partly or completely isolated from the open ocean, frequently do not allow biostratigraphic correlations with the standard geological time scale (GTS).The Miocene stages of the Central Paratethys represent regional chronostratigraphi

read more

Why is it so hard to belong? The difficulties of refugees in their integration processes within Brazilian society and labor market

Abstract The world has recently witnessed a social phenomenon that has been present during the entire history of humanity, but has now taken on greater proportions and impact: the large population displacements of refugees.According to the United Nations, more than 75 million people were in this situation worldwide at the end of 2017, a figure neve

read more

Complete and Partial Lesions of the Pyramidal Tract in the Rat Affect Qualitative Measures of Skilled Movements: Impairment in Fixations as a Model for Clumsy Behavior

Little is known about prenatal and perinatal brain injury resulting in subsequent clumsy behavior in children.One candidate motor system is the pyramidal tract.The tract traverses the entire central nervous system and, through direct and indirect connections to the brainstem and spinal cord sensory and motor nuclei, is involved in the learning and

read more